Marginated aberrant red blood cells induce pathologic vascular stress fluctuations in a computational model of hematologic disorders.

ABSTRACT: Red blood cell (RBC) disorders affect billions worldwide. While alterations in the physical properties of aberrant RBCs and associated hemodynamic changes are readily observed, in conditions such as sickle cell disease and iron deficiency, RBC disorders can also be associated with vascular dysfunction. The mechanisms of vasculopathy in those diseases remain unclear and scant research has explored whether biophysical alterations of RBCs can directly affect vascular function. Here we hypothesize that the purely physical interactions between aberrant RBCs and endothelial cells, due to the margination of stiff aberrant RBCs, play a key role in this phenomenon for a range of disorders. This hypothesis is tested by direct simulations of a cellular scale computational model of blood flow in sickl

SUBMITTER: Cheng X 

PROVIDER: S-EPMC10245698 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature