Leveraging longitudinal diffusion MRI data to quantify differences in white matter microstructural decline in normal and abnormal aging.

ABSTRACT:

Introduction

It is unclear how rates of white matter microstructural decline differ between normal aging and abnormal aging.

Methods

Diffusion MRI data from several well-established longitudinal cohorts of aging [Alzheimer's Neuroimaging Initiative (ADNI), Baltimore Longitudinal Study of Aging (BLSA), Vanderbilt Memory & Aging Project (VMAP)] was free-water corrected and harmonized. This dataset included 1,723 participants (age at baseline: 72.8±8.87 years, 49.5% male) and 4,605 imaging sessions (follow-up time: 2.97±2.09 years, follow-up range: 1-13 years, mean number of visits: 4.42±1.98). Differences in white matter microstructural decline in normal and abnormal agers was assessed.

Results

While we found global decline in white matter in normal/abnormal aging, we f

SUBMITTER: Archer DB 

PROVIDER: S-EPMC10245725 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature