Microbes with higher metabolic independence are enriched in human gut microbiomes under stress.

ABSTRACT: A wide variety of human diseases are associated with loss of microbial diversity in the human gut, inspiring a great interest in the diagnostic or therapeutic potential of the microbiota. However, the ecological forces that drive diversity reduction in disease states remain unclear, rendering it difficult to ascertain the role of the microbiota in disease emergence or severity. One hypothesis to explain this phenomenon is that microbial diversity is diminished as disease states select for microbial populations that are more fit to survive environmental stress caused by inflammation or other host factors. Here, we tested this hypothesis on a large scale, by developing a software framework to quantify the enrichment of microbial metabolisms in complex metagenomes as a function of microbial d

SUBMITTER: Veseli I 

PROVIDER: S-EPMC10245760 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature