Harmonization of CSF and imaging biomarkers for Alzheimer's disease biomarkers: need and practical applications for genetics studies and preclinical classification.

ABSTRACT:

Introduction

In Alzheimer's disease (AD) research, cerebrospinal fluid (CSF) Amyloid beta (Aβ), Tau and pTau are the most accepted and well validated biomarkers. Several methods and platforms exist to measure those biomarkers which leads to challenges in combining data across studies. Thus, there is a need to identify methods that harmonize and standardize these values.

Methods

We used a Z-score based approach to harmonize CSF and amyloid imaging data from multiple cohorts and compared GWAS result using this method with currently accepted methods. We also used a generalized mixture modelling to calculate the threshold for biomarker-positivity.

Results

Z-scores method performed as well as meta-analysis and did not lead to any spurious results. Cutoffs calculated with t

SUBMITTER: Timsina J 

PROVIDER: S-EPMC10245826 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature