Long-range repression by ecdysone receptor on complex enhancers of the insulin receptor gene.

ABSTRACT: The insulin signaling pathway is evolutionarily conserved throughout metazoans, playing key roles in development, growth, and metabolism. Misregulation of this pathway is associated with a multitude of disease states including diabetes, cancer, and neurodegeneration. Genome-wide association studies indicate that natural variants in putative intronic regulatory elements of the human insulin receptor gene ( INSR) are associated with metabolic conditions, however, this gene's transcriptional regulation remains incompletely studied. INSR is widely expressed throughout development and was previously described as a 'housekeeping' gene. Yet, there is abundant evidence that this gene is expressed in a cell-type specific manner, with dynamic regulation in response to environmental sig

SUBMITTER: Thompson K 

PROVIDER: S-EPMC10245858 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature