Conditional control of universal CAR T cells by cleavable OFF-switch adaptors.

ABSTRACT: As living drugs, engineered T cell therapies are revolutionizing disease treatment with their unique functional capabilities. However, they suffer from limitations of potentially unpredictable behavior, toxicities, and non-traditional pharmacokinetics. Engineering conditional control mechanisms responsive to tractable stimuli such as small molecules or light is thus highly desirable. We and others previously developed "universal" chimeric antigen receptors (CARs) that interact with co-administered antibody adaptors to direct target cell killing and T cell activation. Universal CARs are of high therapeutic interest due to their ability to simultaneously target multiple antigens on the same disease or different diseases by combining with adaptors to different antigens. Here, we further enhan

SUBMITTER: Kvorjak M 

PROVIDER: S-EPMC10245878 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature