High Frequencies of Antiviral Effector Memory T_EM Cells and Memory B Cells Mobilized into Herpes Infected Vaginal Mucosa Associated With Protection Against Genital Herpes.

ABSTRACT: Vaginal mucosa-resident anti-viral effector memory B- and T cells appeared to play a crucial role in protection against genital herpes. However, how to mobilize such protective immune cells into the vaginal tissue close to infected epithelial cells remains to be determined. In the present study, we investigate whether and how, CCL28, a major mucosal-associated chemokine, mobilizes effector memory B- and T cells in leading to protecting mucosal surfaces from herpes infection and disease. The CCL28 is a chemoattractant for the CCR10 receptor-expressing immune cells and is produced homeostatically in the human vaginal mucosa (VM). We found the presence of significant frequencies of HSV-specific memory CCR10⁺CD44⁺CD8⁺ T cells, expressing high levels of CCR10 re

SUBMITTER: Dhanushkodi NR 

PROVIDER: S-EPMC10245907 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature