Cell type deconvolution of bulk blood RNA-Seq to reveal biological insights of neuropsychiatric disorders.

ABSTRACT: Genome-wide association studies (GWAS) have uncovered susceptibility loci associated with psychiatric disorders like bipolar disorder (BP) and schizophrenia (SCZ). However, most of these loci are in non-coding regions of the genome with unknown causal mechanisms of the link between genetic variation and disease risk. Expression quantitative trait loci (eQTL) analysis of bulk tissue is a common approach to decipher underlying mechanisms, though this can obscure cell-type specific signals thus masking trait-relevant mechanisms. While single-cell sequencing can be prohibitively expensive in large cohorts, computationally inferred cell type proportions and cell type gene expression estimates have the potential to overcome these problems and advance mechanistic studies. Using bulk RNA-Seq from

SUBMITTER: Boltz T 

PROVIDER: S-EPMC10245943 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature