Multi-omic Profiling Reveals Early Immunological Indicators for Identifying COVID-19 Progressors.

ABSTRACT: The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a rapid response by the scientific community to further understand and combat its associated pathologic etiology. A focal point has been on the immune responses mounted during the acute and post-acute phases of infection, but the immediate post-diagnosis phase remains relatively understudied. We sought to better understand the immediate post-diagnosis phase by collecting blood from study participants soon after a positive test and identifying molecular associations with longitudinal disease outcomes. Multi-omic analyses identified differences in immune cell composition, cytokine levels, and cell subset-specific transcriptomic and epigenomic signatures between individuals on a more serious dis

SUBMITTER: Drake KA 

PROVIDER: S-EPMC10246026 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature