Spatial genomic, biochemical, and cellular mechanisms drive meningioma heterogeneity and evolution.

ABSTRACT: Intratumor heterogeneity underlies cancer evolution and treatment resistance^1-5, but targetable mechanisms driving intratumor heterogeneity are poorly understood. Meningiomas are the most common primary intracranial tumors and are resistant to all current medical therapies^6,7. High-grade meningiomas cause significant neurological morbidity and mortality and are distinguished from low-grade meningiomas by increased intratumor heterogeneity arising from clonal evolution and divergence⁸. Here we integrate spatial transcriptomic and spatial protein profiling approaches across high-grade meningiomas to identify genomic, biochemical, and cellular mechanisms linking intratumor heterogeneity to the molecular, temporal, and spatial evolution of cancer. We show diver

SUBMITTER: Lucas CH 

PROVIDER: S-EPMC10246120 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature