Individual Deviations from Normative Electroencephalographic Connectivity Predict Antidepressant Response.

ABSTRACT: Antidepressant medications yield unsatisfactory treatment outcomes in patients with major depressive disorder (MDD) with modest advantages over the placebo. This modest efficacy is partly due to the elusive mechanisms of antidepressant responses and unexplained heterogeneity in patient's response to treatment - the approved antidepressants only benefit a portion of patients, calling for personalized psychiatry based on individual-level prediction of treatment responses. Normative modeling, a framework that quantifies individual deviations in psychopathological dimensions, offers a promising avenue for the personalized treatment for psychiatric disorders. In this study, we built a normative model with resting-state electroencephalography (EEG) connectivity data from healthy controls of thre

SUBMITTER: Tong X 

PROVIDER: S-EPMC10246152 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature