Residential proximity to dioxin emissions and risk of breast cancer in the sister study cohort.

ABSTRACT: Some dioxins are carcinogenic, but few studies have investigated the relationship between ambient polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F) and risk of breast cancer. We evaluated associations between proximity-based residential exposure to industrial emissions of PCDD/F and breast cancer risk in a large U.S. cohort. Sister Study participants at enrollment (2003-2009) were followed for incident breast cancer through September 2018. After restricting to participants with ≥10 years of residential history prior to enrollment (n = 35,908), we generated 10-year distance- and toxic equivalency quotient (TEQ)-weighted average emissions indices (AEI [g TEQ/km²]) within 3, 5, or 10 km of participants' residences, overall and by facility type. Multivariable Cox regressi

SUBMITTER: Rhee J 

PROVIDER: S-EPMC10246344 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature