All-Atom Simulations Uncover Structural and Dynamical Properties of STING Proteins in the Membrane System.

ABSTRACT: Recent studies have shown that the stimulator of interferon gene (STING) protein plays a central role in the immune system by facilitating the production of type I interferons in cells. The STING signaling pathway is also a prominent activator of cancer-killing T cells that initiate a powerful adaptive immune response. Since biomolecular signaling pathways are complicated and not easily identified through traditional experiments, molecular dynamics (MD) has often been used to study structural and dynamical responses of biological pathways. Here, we carried out MD simulations for full-length chicken and human STING (chSTING and hSTING) proteins. Specifically, we investigated ligand-bound closed (holo) and ligand-unbound open (apo) forms of STING in the membrane system by comparing their con

SUBMITTER: Payne RT 

PROVIDER: S-EPMC10246352 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature