Comprehensive analyses of a CD8⁺ T cell infiltration related gene signature with regard to the prediction of prognosis and immunotherapy response in lung squamous cell carcinoma.

ABSTRACT: Lung squamous cell carcinoma (LUSC) is associated with a worse prognosis than other histological subtypes of non-small cell lung cancer. Due to the vital role of CD8⁺ T cells in anti-tumor immunity, the characterization of CD8⁺ T cell infiltration-related (CTLIR) gene signature in LUSC is worthy of in-depth exploration. In our study, tumor tissues of LUSC patients from Renmin Hospital of Wuhan University were stained by multiplex immunohistochemistry to evaluate the density of infiltrated CD8⁺ T cells and explore the correlation with immunotherapy response. We found that the proportion of LUSC patients who responded to immunotherapy was higher in the high density of CD8⁺ T cell infiltration group than in the low density of CD8⁺ T cell

SUBMITTER: Chen L 

PROVIDER: S-EPMC10246359 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature