Single-cell and spatial transcriptomics reveal changes in cell heterogeneity during progression of human tendinopathy.

ABSTRACT:

Background

Musculoskeletal tissue degeneration impairs the life quality and motor function of many people, especially seniors and athletes. Tendinopathy is one of the most common diseases associated with musculoskeletal tissue degeneration, representing a major global healthcare burden that affects both athletes and the general population, with the clinical presentation of long-term recurring chronic pain and decreased tolerance to activity. The cellular and molecular mechanisms at the basis of the disease process remain elusive. Here, we use a single-cell and spatial RNA sequencing approach to provide a further understanding of cellular heterogeneity and molecular mechanisms underlying tendinopathy progression.

Results

To explore the changes in tendon homeostasis during the

SUBMITTER: Fu W 

PROVIDER: S-EPMC10246392 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature