Infiltrating myeloid cell diversity determines oncological characteristics and clinical outcomes in breast cancer.

ABSTRACT:

Background

Breast cancer presents as one of the top health threats to women around the world. Myeloid cells are the most abundant cells and the major immune coordinator in breast cancer tumor microenvironment (TME), target therapies that harness the anti-tumor potential of myeloid cells are currently being evaluated in clinical trials. However, the landscape and dynamic transition of myeloid cells in breast cancer TME are still largely unknown.

Methods

Myeloid cells were characterized in the single-cell data and extracted with a deconvolution algorithm to be assessed in bulk-sequencing data. We used the Shannon index to describe the diversity of infiltrating myeloid cells. A 5-gene surrogate scoring system was then constructed and evaluated to infer the myeloid cell diversit

SUBMITTER: Yang C 

PROVIDER: S-EPMC10246424 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature