Radiolabeling and in vivo evaluation of lanmodulin with biomedically relevant lanthanide isotopes.

ABSTRACT: Short-lived, radioactive lanthanides comprise an emerging class of radioisotopes attractive for biomedical imaging and therapy applications. To deliver such isotopes to target tissues, they must be appended to entities that target antigens overexpressed on the target cell's surface. However, the thermally sensitive nature of biomolecule-derived targeting vectors requires the incorporation of these isotopes without the use of denaturing temperatures or extreme pH conditions; chelating systems that can capture large radioisotopes under mild conditions are therefore highly desirable. Herein, we demonstrate the successful radiolabeling of the lanthanide-binding protein, lanmodulin (LanM), with medicinally relevant radioisotopes: ¹⁷⁷Lu, ^132/135La and ⁸⁹Zr. Radio

SUBMITTER: Martin KE 

PROVIDER: S-EPMC10246553 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature