LENS: Landscape of Effective Neoantigens Software.

ABSTRACT:

Motivation

Elimination of cancer cells by T cells is a critical mechanism of anti-tumor immunity and cancer immunotherapy response. T cells recognize cancer cells by engagement of T cell receptors with peptide epitopes presented by major histocompatibility complex (MHC) molecules on the cancer cell surface. Peptide epitopes can be derived from antigen proteins coded for by multiple genomic sources. Bioinformatics tools used to identify tumor-specific epitopes via analysis of DNA and RNA sequencing data have largely focused on epitopes derived from somatic variants, though a smaller number have evaluated potential antigens from other genomic sources.

Results

We report here an open-source workflow utilizing the Nextflow DSL2 workflow manager, Landscape of Effective Neoantigen

SUBMITTER: Vensko SP 

PROVIDER: S-EPMC10246587 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature