Canonical Response Parameterization: Quantifying the structure of responses to single-pulse intracranial electrical brain stimulation.

ABSTRACT: Single-pulse electrical stimulation in the nervous system, often called cortico-cortical evoked potential (CCEP) measurement, is an important technique to understand how brain regions interact with one another. Voltages are measured from implanted electrodes in one brain area while stimulating another with brief current impulses separated by several seconds. Historically, researchers have tried to understand the significance of evoked voltage polyphasic deflections by visual inspection, but no general-purpose tool has emerged to understand their shapes or describe them mathematically. We describe and illustrate a new technique to parameterize brain stimulation data, where voltage response traces are projected into one another using a semi-normalized dot product. The length of timepoints fr

SUBMITTER: Miller KJ 

PROVIDER: S-EPMC10246848 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature