Mesoscale, long-time mixing of chromosomes and its connection to polymer dynamics.

ABSTRACT: Chromosomes are arranged in distinct territories within the nucleus of animal cells. Recent experiments have shown that these territories overlap at their edges, suggesting partial mixing during interphase. Experiments that knock-down of condensin II proteins during interphase indicate increased chromosome mixing, which demonstrates control of the mixing. In this study, we use a generic polymer simulation to quantify the dynamics of chromosome mixing over time. We introduce the chromosome mixing index, which quantifies the mixing of distinct chromosomes in the nucleus. We find that the chromosome mixing index in a small confinement volume (as a model of the nucleus), increases as a power-law of the time, with the scaling exponent varying non-monotonically with self-interaction and volume f

SUBMITTER: Bajpai G 

PROVIDER: S-EPMC10246856 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature