Ingested nitrate, disinfection by-products, and risk of colon and rectal cancers in the Iowa Women's Health Study cohort.

ABSTRACT:

Background

N-nitroso compounds (NOC) formed endogenously after nitrate/nitrite ingestion and disinfection by-products (DBPs) are suspected colorectal carcinogens, but epidemiologic evidence of these associations is limited.

Objectives

We investigated the relationship between drinking water exposures and incident colorectal cancers in a cohort of postmenopausal women.

Methods

Using historical nitrate-nitrogen (NO₃-N) measurements and estimates of total trihalomethanes (TTHM), the sum of 5 or 6 haloacetic acids (HAAs), and individual DBPs in public water supplies (PWS), we computed average exposures and years of exposure above one-half the U.S. maximum contaminant level (>1/2-MCL; >5 mg/L NO₃-N and >40 μg/L TTHM). Nitrate/nitrite intakes from dieta

SUBMITTER: Jones RR 

PROVIDER: S-EPMC10247223 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature