Identification of High Platelet Reactivity Despite ADP P2Y ₁₂ Inhibitor Treatment: Two Populations in the Vasodilator-Stimulated Phosphoprotein Assay and Variable PFA-P2Y Shapes of Curve.

ABSTRACT: Introduction  Response to ADP P2Y ₁₂ receptor inhibition by clopidogrel can be evaluated by various techniques. Here, we compared a functional rapid point-of-care technique (PFA-P2Y) with the degree of biochemical inhibition assessed by the VASP/P2Y ₁₂ assay. Methods  Platelet response to clopidogrel was investigated in 173 patients undergoing elective intracerebral stenting (derivation cohort n  = 117; validation cohort n  = 56). High platelet reactivity (HPR) was defined as PFA-P2Y occlusion time <106 seconds or VASP/P2Y ₁₂ platelet reactivity index (PRI) >50%. Results  In the derivation cohort, receiver operator characteristics analysis for the ability of PFA-P2Y to detect biochemical HPR showed high specificity (98.4%)

SUBMITTER: Mariethoz C 

PROVIDER: S-EPMC10247305 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature