Ontology highlight
ABSTRACT:
SUBMITTER: Foronda H
PROVIDER: S-EPMC10247384 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Foronda Hector H Fu Yangxue Y Covarrubias-Pinto Adriana A Bocker Hartmut T HT González Alexis A Seemann Eric E Franzka Patricia P Bock Andrea A Bhaskara Ramachandra M RM Liebmann Lutz L Hoffmann Marina E ME Katona Istvan I Koch Nicole N Weis Joachim J Kurth Ingo I Gleeson Joseph G JG Reggiori Fulvio F Hummer Gerhard G Kessels Michael M MM Qualmann Britta B Mari Muriel M Dikić Ivan I Hübner Christian A CA
Nature 20230524 7964
Membrane-shaping proteins characterized by reticulon homology domains play an important part in the dynamic remodelling of the endoplasmic reticulum (ER). An example of such a protein is FAM134B, which can bind LC3 proteins and mediate the degradation of ER sheets through selective autophagy (ER-phagy)<sup>1</sup>. Mutations in FAM134B result in a neurodegenerative disorder in humans that mainly affects sensory and autonomic neurons<sup>2</sup>. Here we report that ARL6IP1, another ER-shaping pr ...[more]