Circadian Rest-Activity Rhythms, Delirium Risk, and Progression to Dementia.

ABSTRACT:

Objective

Delirium is a complex neurocognitive syndrome suspected to be bidirectionally linked to dementia. Circadian rhythm disturbances likely contribute to dementia pathogenesis, but whether these disturbances are related to delirium risk and progression to all-cause dementia is unknown.

Methods

We analyzed continuous actigraphy data from 53,417 middle-aged or older UK Biobank participants during a median 5 years of follow-up. Four measures were used to characterize the 24-hour daily rest-activity rhythms (RARs): normalized amplitude, acrophase representing the peak activity time, interdaily stability, and intradaily variability (IV) for fragmentation of the rhythm. Cox proportional hazards models examined whether RARs predicted incident delirium (n = 551) and progression

SUBMITTER: Gao L 

PROVIDER: S-EPMC10247440 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature