Outdoor air pollution and histologic composition of normal breast tissue.

ABSTRACT:

Background

Biologic pathways underlying the association between outdoor air pollution and breast cancer risk are poorly understood. Breast tissue composition may reflect cumulative exposure to breast cancer risk factors and has been associated with breast cancer risk among patients with benign breast disease. Herein, we evaluated whether fine particulate matter (PM_2.5) was associated with the histologic composition of normal breast tissue.

Methods

Machine-learning algorithms were applied to digitized hematoxylin and eosin-stained biopsies of normal breast tissue to quantify the epithelium, stroma, adipose and total tissue area from 3,977 individuals aged 18-75 years from a primarily Midwestern United States population who donated breast tissue samples to the Susan

SUBMITTER: Ish JL 

PROVIDER: S-EPMC10247451 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature