Pleiotropic loci for cannabis use disorder severity in multi-ancestry high-risk populations.

ABSTRACT: Cannabis use disorder (CUD) is common and has in part a genetic basis. The risk factors underlying its development likely involve multiple genes that are polygenetic and interact with each other and the environment to ultimately lead to the disorder. Co-morbidity and genetic correlations have been identified between CUD and other disorders and traits in select populations primarily of European descent. If two or more traits, such as CUD and another disorder, are affected by the same genetic locus, they are said to be pleiotropic. The present study aimed to identify specific pleiotropic loci for the severity level of CUD in three high-risk population cohorts: American Indians (AI), Mexican Americans (MA), and European Americans (EA). Using a previously developed computational method based o

SUBMITTER: Peng Q 

PROVIDER: S-EPMC10247496 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature