Polygenic risk scores point toward potential genetic mechanisms of type 2 myocardial infarction in people with HIV.

ABSTRACT:

Background

People with human immunodeficiency virus (HIV) infection (PWH) are at higher risk of myocardial infarction (MI) than those without HIV. About half of MIs in PWH are type 2 (T2MI), resulting from mismatch between myocardial oxygen supply and demand, in contrast to type 1 MI (T1MI), which is due to primary plaque rupture or coronary thrombosis. Despite worse survival and rising incidence in the general population, evidence-based treatment recommendations for T2MI are lacking. We used polygenic risk scores (PRS) to explore genetic mechanisms of T2MI compared to T1MI in PWH.

Methods

We derived 115 PRS for MI-related traits in 9541 PWH enrolled in the Centers for AIDS Research Network of Integrated Clinical Systems cohort with adjudicated T1MI and T2MI. We applied mult

SUBMITTER: Lee WJ 

PROVIDER: S-EPMC10247524 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature