The antidepressant-like effect of guanosine involves the modulation of adenosine A₁ and A_2A receptors.

ABSTRACT: Guanosine has been considered a promising candidate for antidepressant responses, but if this nucleoside could modulate adenosine A₁ (A₁R) and A_2A (A_2AR) receptors to exert antidepressant-like actions remains to be elucidated. This study investigated the role of A₁R and A_2AR in the antidepressant-like response of guanosine in the mouse tail suspension test and molecular interactions between guanosine and A₁R and A₂AR by docking analysis. The acute (60 min) administration of guanosine (0.05 mg/kg, p.o.) significantly decreased the immobility time in the tail suspension test, without affecting the locomotor performance in the open-field test, suggesting an antidepressant-like effect. This behavioral respo

SUBMITTER: Camargo A 

PROVIDER: S-EPMC10247657 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature