Eftrenonacog Alfa: A Review in Haemophilia B.

ABSTRACT: Eftrenonacog alfa (Alprolix^®) is an extended half-life recombinant factor IX (rFIX)-Fc fusion protein (hereafter referred to as rFIXFc). Administered as an intravenous bolus, it is approved for prophylactic use and the treatment of bleeding in patients with haemophilia B in various countries worldwide, including those of the EU, as well as the USA. In multinational, phase III trials, rFIXFc was effective for the prophylaxis, perioperative management or on-demand treatment of bleeding in male patients with severe haemophilia B regardless of age and irrespective of whether or not they had been previously treated with FIX replacement products. Prophylactic efficacy was maintained over the longer term (up to 5 years) in previously treated patients. rFIXFc effectiveness in the real-w

SUBMITTER: Lamb YN 

PROVIDER: S-EPMC10247827 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature