Assessing cocaine motivational value: Comparison of brain reactivity bias toward cocaine cues and cocaine demand.

ABSTRACT: The behavioral economic measure drug demand and the neural measure late positive potential (LPP) are two measures of motivational value that have been associated with drug relapse risk and treatment outcomes. Despite having overlapping themes, no studies have directly compared drug demand and LPP. Participants (N = 59) included treatment-seeking individuals with cocaine use disorder that had completed both a baseline cocaine demand task and an electroencephalogram (EEG) picture-viewing task of drug-related and pleasant picture cues. Associations between the LPP difference score amplitude (drug-pleasant) and five demand indices (Q₀, essential value [EV], O_max, P_max, and breakpoint [BP]) were evaluated via Bayesian generalized linear modeling

SUBMITTER: Webber HE 

PROVIDER: S-EPMC10247896 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature