Bevacizumab is associated with cerebral microstructural alterations: a DTI study in high-grade glioma.

ABSTRACT:

Background

For recurrent high-grade glioma, especially glioblastoma, no standard of care treatment exists. Due to the prolongation of progression-free survival and a cortiocosteroid-sparing effect, bevacizumab is often used in this condition. Despite initial clinical responses, there is growing evidence that bevacizumab may potentiate microstructural alterations which may cause cognitive decline, mostly affecting learning and memory.

Methods

To investigate bevacizumab-associated microstructural damage of defined regions of interest (ROIs) in the white matter, diffusion tensor imaging (DTI) was performed in 10 patients with a case history or third-party report for neurological dysfunction concerning cognitive performance. Serial DTI data before and under bevacizumab were coll

SUBMITTER: Kassubek R 

PROVIDER: S-EPMC10247958 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature