Causal relationship between circulating immune cells and the risk of type 2 diabetes: a Mendelian randomization study

ABSTRACT:

Objectives

Though type 2 diabetes (T2D) has been known as a metabolic disease caused by multiple factors, the etiology remains insufficiently understood. Here, we aimed to figure out whether circulating immune cell profiles causally impact T2D liability.

Methods

We applied one genome-wide association study (GWAS) summary statistics of blood traits in 563,085 participants from the Blood Cell Consortium and another GWAS of flow cytometric profile of lymphocyte subsets comprising 3,757 Sardinians to identify genetically predicted blood immune cells. We also obtained GWAS summary statistics in 898,130 individuals from the DIAGRAM Consortium to evaluate genetically predicted T2D. We primarily used inverse variance weighted (IVW) and weighted median methods to perform Mendelian

SUBMITTER:  

PROVIDER: S-EPMC10247959 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature