Investigating the tumor-immune microenvironment through extracellular vesicles from frozen patient biopsies and 3D cultures.

ABSTRACT: Melanomas are highly immunogenic tumors that have been shown to activate the immune response. Nonetheless, a significant portion of melanoma cases are either unresponsive to immunotherapy or relapsed due to acquired resistance. During melanomagenesis, melanoma and immune cells undergo immunomodulatory mechanisms that aid in immune resistance and evasion. The crosstalk within melanoma microenvironment is facilitated through the secretion of soluble factors, growth factors, cytokines, and chemokines. In addition, the release and uptake of secretory vesicles known as extracellular vesicles (EVs) play a key role in shaping the tumor microenvironment (TME). Melanoma-derived EVs have been implicated in immune suppression and escape, promoting tumor progression. In the context of cancer patients,

SUBMITTER: Al Hrout A 

PROVIDER: S-EPMC10248017 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature