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Cell-based and cell-free immunotherapies for glioblastoma: current status and future directions.


ABSTRACT: Glioblastoma (GBM) is among the most fatal and recurring malignant solid tumors. It arises from the GBM stem cell population. Conventional neurosurgical resection, temozolomide (TMZ)-dependent chemotherapy and radiotherapy have rendered the prognosis of patients unsatisfactory. Radiotherapy and chemotherapy can frequently induce non-specific damage to healthy brain and other tissues, which can be extremely hazardous. There is therefore a pressing need for a more effective treatment strategy for GBM to complement or replace existing treatment options. Cell-based and cell-free immunotherapies are currently being investigated to develop new treatment modalities against cancer. These treatments have the potential to be both selective and successful in minimizing off-target collateral harm in the normal brain. In this review, several aspects of cell-based and cell-free immunotherapies related to GBM will be discussed.

SUBMITTER: Wang M 

PROVIDER: S-EPMC10248152 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Cell-based and cell-free immunotherapies for glioblastoma: current status and future directions.

Wang Mingming M   Wang Xiaojie X   Jin Xiaoyan X   Zhou Jingjing J   Zhang Yufu Y   Yang Yiyuan Y   Liu Yusi Y   Zhang Jing J  

Frontiers in immunology 20230525


Glioblastoma (GBM) is among the most fatal and recurring malignant solid tumors. It arises from the GBM stem cell population. Conventional neurosurgical resection, temozolomide (TMZ)-dependent chemotherapy and radiotherapy have rendered the prognosis of patients unsatisfactory. Radiotherapy and chemotherapy can frequently induce non-specific damage to healthy brain and other tissues, which can be extremely hazardous. There is therefore a pressing need for a more effective treatment strategy for  ...[more]

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