Unearths IFNB1 immune infiltrates in SOP-related ossification of ligamentum flavum pathogenesis.

ABSTRACT:

Background

Ossification of ligamentum flavum (OLF) is a hidden, indolent disease condition with variable unexplained etiology and pathology. Growing evidences show a correlation between senile osteoporosis (SOP) and OLF, but the fundamental relationship between SOP and OLF remains unclear. Therefore, the purpose of this work is to investigate unique SOP-related genes and their potential functions in OLF.

Methods

Gene Expression Omnibus (GEO) database was utilized to gather the mRNA expression data (GSE106253) and then analyzed by R software. A variety of methods, including ssGSEA, machine learning (LASSO and SVM-RFE), GO and KEGG enrichment, PPI network, transcription factor enrichment analysis (TFEA), GSEA and xCells were employed to verified the critical genes and signalin

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10248278 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature