Intra-subject variability in oscillometry correlates with acute rejection and CLAD post-lung transplant.

ABSTRACT:

Background

Chronic lung allograft dysfunction (CLAD) is the major cause of death post-lung transplantation, with acute cellular rejection (ACR) being the biggest contributing risk factor. Although patients are routinely monitored with spirometry, FEV₁ is stable or improving in most ACR episodes. In contrast, oscillometry is highly sensitive to respiratory mechanics and shown to track graft injury associated with ACR and its improvement following treatment. We hypothesize that intra-subject variability in oscillometry measurements correlates with ACR and risk of CLAD.

Methods

Of 289 bilateral lung recipients enrolled for oscillometry prior to laboratory-based spirometry between December 2017 and March 2020, 230 had ≥ 3 months and 175 had ≥ 6 months of follow-up. Wh

SUBMITTER: Vasileva A 

PROVIDER: S-EPMC10248398 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature