Tuberculosis infection following immune checkpoint inhibitor treatment for advanced cancer: a case report and literature review.

ABSTRACT:

Objective

To investigate the clinical features of active tuberculosis (TB) infection due to immune checkpoint inhibitors (ICIs) treatment in patients with advanced cancer.

Methods

We report the diagnosis and treatment of a case of pulmonary malignancy (squamous cell carcinoma, cT4N3M0 IIIC), secondary to active TB infection following ICIs therapy. Moreover, we summarize and analyze other related cases collected from the China National Knowledge Infrastructure (CNKI), Wanfang Database, PubMed, the Web of Science, and EMBASE (up to October 2021).

Results

A total of 23 patients, including 20 males and 3 females who were aged 49-87 years with a median age of 65 years, were included in the study. Twenty-two patients were diagnosed by Mycobacterium tuberculosis culture or D

SUBMITTER: Lin C 

PROVIDER: S-EPMC10248429 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature