Causal associations between human gut microbiota and cholelithiasis: a mendelian randomization study.

ABSTRACT:

Background

There was some evidence that gut microbiota was closely related to cholelithiasis, but the causal relationship between them remained unclear. In this study, we try to use Two-sample Mendelian randomization (MR) to clarify the potential causal relationship between gut microbiota and cholelithiasis.

Methods

Summary Genome-Wide Association Studies (GWAS) statistical data for gut microbiota was obtained from MiBioGen, and the data of cholelithiasis was obtained from UK Biobank (UKB). Two-sample MR analyses were performed to assess causalities between gut microbiota and cholelithiasis mainly using the inverse-variance weighted (IVW) method. Sensitivity analyses were used to determine the robustness of the MR results. Reverse MR analyses were performed to examine the re

SUBMITTER: Li W 

PROVIDER: S-EPMC10248444 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature