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Cu(ii)-catalyzed C–N coupling of 2-aminobenzothiazoles with boronic acids at room temperature† † Electronic supplementary information (ESI) available: A comprehensive report on the experimental approaches, procedures and materials employed etc. were included in the ESI. The characterization data with spectral details (1H, 13C NMR) of the prepared compounds are also comprised in this section. See DOI: https://doi.org/10.1039/d3ra02979d

ABSTRACT: A Cu(ii)-catalyzed, effective C–N coupling of 2-aminobenzothiazoles with boronic acids in acetonitrile under open vessel chemistry was achieved. This protocol demonstrates the N-arylation of 2-aminobenzothiazoles with a broad range of differently substituted phenylboronic acids at room temperature and accomplishes moderate to excellent yields of the desired products. Under the optimized condition, phenylboronic acids bearing halogen at the para and meta positions were found to be more fruitful. A Cu(ii)-catalyzed, effective C–N coupling of 2-aminobenzothiazoles with boronic acids in acetonitrile under open vessel chemistry was achieved.

SUBMITTER: Radhika S

PROVIDER: S-EPMC10248544 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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