Identification of immune-related genes and patient selection for hepatocellular carcinoma immunotherapy.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a malignant disease with a poor prognosis. Among the treatment strategies for HCC, tumor immunotherapy (TIT) is a promising research hotspot, in which identifying novel immune-related biomarkers and selecting suitable patient population are urgent issues to be solved.

Methods

In this study, an abnormal expression map of HCC cell genes was constructed using public high-throughput data from 7,384 samples (3,941 HCC vs. 3,443 non-HCC tissues). Through single-cell RNA sequencing (scRNA-seq) cell trajectory analysis, the genes defined as potential drivers of HCC cell differentiation and development were selected. By screening for both immune-related genes and those associated with high differentiation potential in HCC cell devel

SUBMITTER: Chen ZD 

PROVIDER: S-EPMC10248567 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature