LINC00638/hsa-miR-29b-3p axis-mediated high expression of CDCA4 correlates with tumor immune infiltration and hepatocellular carcinoma progression

ABSTRACT:

Background

This study sought to explore the role of cell division cycle-associated protein 4 (CDCA4) in liver hepatocellular carcinoma (LIHC) patients.

Methods

The RNA-sequencing raw count data and the respective clinical information of 33 different LIHC cancer and normal tissues were collected from the Genotype Tissue Expression (GTEX) and The Cancer Genome Atlas (TCGA) databases. The expression of CDCA4 in LIHC was determined via the University of Alabama at Birmingham Cancer Data Analysis Portal (UALCAN) database. The PrognoScan database was used to examine the correlation between CDCA4 and overall survival (OS) in LIHC. The interaction between the potential upstream microRNAs and the long non-coding RNAs (lncRNAs) and CDCA4 was explored using the Encyclopedia of RNA I

SUBMITTER: Wang B 

PROVIDER: S-EPMC10248574 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature