Identification of key genes in HER2-positive breast cancer with brain metastasis via bioinformatics methods.

ABSTRACT:

Background

Brain metastasis (BM) represents one of the most common advanced disease states in breast cancer (BC), especially in human epidermal growth factor receptor 2 (HER2)-positive BC, and is associated with poor survival outcomes.

Methods

In this study, in-depth analysis of the microarray data from the GSE43837 dataset with 19 BM samples of HER2-positive BC patients and 19 HER2-positive nonmetastatic primary BC samples was conducted. The differentially expressed genes (DEGs) between BM and primary BC samples were identified and function enrichment analysis of the DEGs was conducted to identify potential biological functions. The hub genes were identified by constructing the protein-protein interaction (PPI) network using STRING and Cytoscape. UALCAN and Kaplan-Meier plo

SUBMITTER: Yang Z 

PROVIDER: S-EPMC10248581 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature