Genomic analysis of Indian isolates of Plasmodium falciparum: Implications for drug resistance and virulence factors.

ABSTRACT: The emergence of drug resistance to frontline treatments such as Artemisinin-based combination therapy (ACT) is a major obstacle to the control and eradication of malaria. This problem is compounded by the inherent genetic variability of the parasites, as many established markers of resistance do not accurately predict the drug-resistant status. There have been reports of declining effectiveness of ACT in the West Bengal and Northeast regions of India, which have traditionally been areas of drug resistance emergence in the country. Monitoring the genetic makeup of a population can help to identify the potential for drug resistance markers associated with it and evaluate the effectiveness of interventions aimed at reducing the spread of malaria. In this study, we performed whole genome sequ

SUBMITTER: Choubey D 

PROVIDER: S-EPMC10248731 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature