Genetic Risk Factors Associated With Preeclampsia and Hypertensive Disorders of Pregnancy.

ABSTRACT:

Importance

A genetic contribution to preeclampsia susceptibility has been established but is still incompletely understood.

Objective

To disentangle the underlying genetic architecture of preeclampsia and preeclampsia or other maternal hypertension during pregnancy with a genome-wide association study (GWAS) of hypertensive disorders of pregnancy.

Design, setting, and participants

This GWAS included meta-analyses in maternal preeclampsia and a combination phenotype encompassing maternal preeclampsia and preeclampsia or other maternal hypertensive disorders. Two overlapping phenotype groups were selected for examination, namely, preeclampsia and preeclampsia or other maternal hypertension during pregnancy. Data from the Finnish Genetics of Pre-eclampsia Consortium (FIN

SUBMITTER: Tyrmi JS 

PROVIDER: S-EPMC10248811 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature