Hysterectomy, bilateral oophorectomy, and breast cancer risk in a racially diverse prospective cohort study.

ABSTRACT:

Background

Gynecologic surgery is hypothesized to reduce risk of breast cancer; however, associations may be modified by subsequent hormone use. Our objective was to examine the association between gynecologic surgery and breast cancer incidence considering the use of hormone therapy.

Methods

The Sister Study is a prospective cohort of initially breast cancer-free women aged 35-74 years with a sister who had breast cancer. We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between gynecologic surgery (no surgery, hysterectomy only, bilateral oophorectomy with or without hysterectomy) and incident breast cancer among 50 701 women.

Results

History of gynecologic surgery was common, with 13.8% re

SUBMITTER: Lovett SM 

PROVIDER: S-EPMC10248837 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature