Germline genetic variants and pediatric rhabdomyosarcoma outcomes: a report from the Children's Oncology Group.

ABSTRACT:

Background

Relative to other pediatric cancers, survival for rhabdomyosarcoma (RMS) has not improved in recent decades, suggesting the need to enhance risk stratification. Therefore, we conducted a genome-wide association study for event-free survival (EFS) and overall survival (OS) to identify genetic variants associated with outcomes in individuals with RMS.

Methods

The study included 920 individuals with newly diagnosed RMS who were enrolled in Children's Oncology Group protocols. To assess the association of each single nucleotide polymorphism (SNP) with EFS and OS, we estimated hazard ratios (HRs) and 95% confidence intervals (CIs) using multivariable Cox proportional hazards models, adjusted for clinical covariates. All statistical tests were two sided. We also perform

SUBMITTER: Martin-Giacalone BA 

PROVIDER: S-EPMC10248851 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature