Dualistic classification of high grade serous ovarian carcinoma has its root in spatial heterogeneity.

ABSTRACT:

Introduction

Widespread intra-peritoneal metastases is a main feature of high grade serous ovarian carcinoma (HGSOC). Recently, the extent of tumour heterogeneity was used to evaluate the cancer genomes among multi-regions in HGSOC. However, there is no consensus on the effect of tumour heterogeneity on the evolution of the tumour metastasis process in HGSOC.

Objectives

We performed whole-exome sequencing in multiple regions of matched primary and metastatic HGSOC specimens to reveal the genetic mechanisms of ovarian tumourigenesis and malignant progression.

Methods

63 samples (including ovarian carcinoma, omentum metastasis, and normal tissues) were used. We analyzed the genomic heterogeneity, traced the subclone dissemination and establishment history and compared t

SUBMITTER: Sun T 

PROVIDER: S-EPMC10248863 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature