Sex differences in pharmacological interventions and their effects on lifespan and healthspan outcomes: a systematic review.

ABSTRACT: With an increasing aging population, the burden of age-related diseases magnifies. To alleviate this burden, geroprotection has been an area of intense research focus with the development of pharmacological interventions that target lifespan and/or healthspan. However, there are often sex differences, with compounds mostly tested in male animals. Given the importance of considering both sexes in preclinical research, this neglects potential benefits for the female population, as interventions tested in both sexes often show clear sexual dimorphisms in their biological responses. To further understand the prevalence of sex differences in pharmacological geroprotective intervention studies, we performed a systematic review of the literature according to the PRISMA guidelines. Seventy-two stu

SUBMITTER: Knufinke M 

PROVIDER: S-EPMC10249017 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature