Ontology highlight
ABSTRACT:
SUBMITTER: Erdonmez B
PROVIDER: S-EPMC10249096 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Erdönmez Burak B Altıntop Mehlika Dilek MD Akalın Çiftçi Gülşen G Özdemir Ahmet A Ece Abdulilah A
ACS omega 20230524 22
In an endeavor to identify small molecules for the management of non-small-cell lung carcinoma, 10 new hydrazone derivatives (<b>3a-j</b>) were synthesized. MTT test was conducted to examine their cytotoxic activities against human lung adenocarcinoma (A549) and mouse embryonic fibroblast (L929) cells. Compounds <b>3a</b>, <b>3e</b>, <b>3g</b>, and <b>3i</b> were determined as selective antitumor agents on A549 cell line. Further studies were conducted to figure out their mode of action. Compoun ...[more]