Pd-Catalyzed 1,3-Alkenylarylation of Skipped Diene via Metal Migration.

ABSTRACT: We disclose a palladium-catalyzed difunctionalization of skipped diene with alkenyl triflates and arylboronic acids to produce 1,3-alkenylarylated products. The reaction proceeded efficiently with Pd(acac)₂ as a catalyst and CsF as a base for a wide range of electron-deficient and electron-rich arylboronic acids as well as oxygen-heterocyclic, sterically hindered, and complex natural product-derived alkenyl triflates bearing various functional groups. The reaction produced 3-aryl-5-alkenylcyclohexene derivatives with 1,3-syn-disubstituted stereochemistry.

SUBMITTER: Chesley LJ 

PROVIDER: S-EPMC10249098 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature